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EGFP Reporters for Direct and Sensitive Detection of Mutagenic Bypass of DNA Lesions.

Biomolecules - 13 Jun 2020

Rodriguez-Alvarez Marta, Kim Daria, Khobta Andriy

Abstract excerpt

The sustainment of replication and transcription of damaged DNA is essential for cell survival under genotoxic stress; however, the damage tolerance of these key cellular functions comes at the expense of fidelity. Thus, translesion DNA synthesis (TLS) over damaged nucleotides is a major source of point mutations found in cancers; whereas erroneous bypass of damage by RNA polymerases may contribute to cancer and...

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PMID: 32545792
DOI: 10.3390/biom10060902
PMCID: PMC7357151

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