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Article

Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy.

Disease models & mechanisms - 30 Jul 2018

Erstad Derek J, Sojoodi Mozhdeh, Taylor Martin S, Ghoshal Sarani, Razavi Allen A, Graham-O'Regan Katherine A, Bardeesy Nabeel, Ferrone Cristina R, Lanuti Michael, Caravan Peter, Tanabe Kenneth K, Fuchs Bryan C

Abstract excerpt

Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable growth kinetics, making them useful for trialing novel therapeutics. Here, we describe surgical techniques for orthotopic and heterotopic pancreatic ductal adenocarcinoma (PDAC) tumor implantation and characterize phenotypes based on implantation site.Mice...

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PMID: 29903803
DOI: 10.1242/dmm.034793
PMCID: PMC6078400

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