Article

Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model

2022-10-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Pancreatic cancer (PC) has a poor prognosis, and most patients present with either locally advanced or distant metastatic disease. Irreversible Electroporation (IRE) is a non-thermal method of ablation used clinically in locally advanced PC, but most patients eventually develop distant recurrence. We have previously shown that IRE alone is capable of generating protective, n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b57051df-e26d-543f-bb61-be4fafa579f4
DOI: 10.1101/2022.10.04.510847

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic modelDOI 10.1101/2022.10.04.510847Read

Reprogramming the Tolerogenic Immune Response Against Pancreatic Cancer Metastases by Lipid Nanoparticles Delivering a STING Agonist Plus Mutant KRAS mRNA.Semantic proximity Read

CSF-1R–Dependent Lethal Hepatotoxicity When Agonistic CD40 Antibody Is Given before but Not after ChemotherapySemantic proximity Read

Combined KRAS Inhibition and Immune Therapy Generates Durable Complete Responses in an Autochthonous PDAC ModelSemantic proximity Read

Advancing Immunotherapy in Pancreatic Cancer: A Brief Review of Emerging Adoptive Cell TherapiesSemantic proximity Read

Current advances in immunotherapy for KRAS-Mutant pancreatic cancer.Semantic proximity Read

An easily adopted murine model of distal pancreatectomy for investigating immunotherapy efficacy in resectable pancreatic adenocarcinomaSemantic proximity Read

PIK3CA in <i> Kras <sup>G12D</sup> /Trp53 <sup>R172H</sup> </i> Tumor Cells Promotes Immune Evasion by Limiting Infiltration of T Cells in a Model of Pancreatic CancerSemantic proximity Read

Clinically relevant orthotopic pancreatic cancer models for adoptive T cell therapySemantic proximity Read

Oncolytic adenovirus delivery of neoantigens sensitizes low-mutation tumors to anti-PD-1 therapy and prevents metastasis.Semantic proximity Read

Targeting tumor tolerance: A new hope for pancreatic cancer therapy?Semantic proximity Read

Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse modelSemantic proximity Read

Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironmentSemantic proximity Read