Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

23 Apr 2021

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with an overall survival rate of less than 7-8%, emphasizing the need for novel effective therapeutics against PDAC. However only a fraction of therapeutics which seemed promising in the laboratory environment will eventually reach the clinic. One of the main reasons behind this low success rate is the complex tumor microenvironment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to Cancer Cells and Metastasis
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33895214
DOI: 10.1016/j.addr.2021.04.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo modelsPMID 33895214Read ↗

Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systemsSemantic proximity Read ↗

Pancreatic Cancer Patient-Derived Organoid Platforms: A Clinical Tool to Study Cell- and Non-Cell-Autonomous Mechanisms of Treatment ResponseSemantic proximity Read ↗

Multicellular Modelling of Difficult-to-Treat Gastrointestinal Cancers: Current Possibilities and ChallengesSemantic proximity Read ↗

Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid developmentSemantic proximity Read ↗

The Diverse Applications of Pancreatic Ductal Adenocarcinoma OrganoidsSemantic proximity Read ↗

The Heterogeneity of the Tumor Microenvironment as Essential Determinant of Development, Progression and Therapy Response of Pancreatic CancerSemantic proximity Read ↗

Pancreatic Cancer and Its Microenvironment-Recent Advances and Current Controversies.Semantic proximity Read ↗

Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional CulturesSemantic proximity Read ↗

A pancreatic cancer organoid-in-matrix platform shows distinct sensitivities to T cell killingSemantic proximity Read ↗

Challenges in genomic analysis of model systems and primary tumors of pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic ResistanceSemantic proximity Read ↗

Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.