Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene Expression

Abstract excerpt

Abstract Macrophage activation by bacterial LPS leads to induction of a complex inflammatory gene program dependent on numerous transcription factor families. The transcription factor Ikaros has been shown to play a critical role in lymphoid cell development and differentiation; however, its function in myeloid cells and innate immune responses is less appreciated. Using comprehensive genomic analysis of...