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Ikaros-Associated Diseases: From Mice to Humans and Back Again

16 Jul 2021

Abstract excerpt

The normal expression of Ikaros (IKZF1) is important for the proper functioning of both the human and murine immune systems. Whilst our understanding of IKZF1 in the immune system has been greatly enhanced by the study of mice carrying mutations inIkzf1, analyses of human patients carrying germlineIKZF1mutations have been instrumental in understanding its biological role within the human immune system and its...

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PMID: 34354970
DOI: 10.3389/fped.2021.705497

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