Article
Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors.
The Journal of biological chemistry - 17 Jun 2011
Masuho Ikuo, Wakasugi-Masuho Hideko, Posokhova Ekaterina N, Patton Joseph R, Martemyanov Kirill A
Abstract excerpt
The R7 family of regulators of G protein signaling (RGS) proteins, comprising RGS6, RGS7, RGS9, and RGS11, regulate neuronal G protein signaling pathways. All members of the R7 RGS form trimeric complexes with the atypical G protein β subunit, Gβ5, and membrane anchor R7BP or R9AP. Association with Gβ5 and membrane anchors has been shown to be critical for maintaining proteolytic stability of the R7 RGS proteins....
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