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Article

Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans.

BMC genomics - 11 Jun 2018

Winter Jean M, Curry Natasha L, Gildea Derek M, Williams Kendra A, Lee Minnkyong, Hu Ying, Crawford Nigel P S

Abstract excerpt

BACKGROUND: It is well known that development of prostate cancer (PC) can be attributed to somatic mutations of the genome, acquired within proto-oncogenes or tumor-suppressor genes. What is less well understood is how germline variation contributes to disease aggressiveness in PC patients. To map germline modifiers of aggressive neuroendocrine PC, we generated a genetically diverse F2 intercross population using...

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Share to Crosses, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nerve Tissue Proteins

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Source

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Identifiers

PMID: 29890952
DOI: 10.1186/s12864-018-4827-2
PMCID: PMC5996485

Genes

DNAJC10
STYXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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