Article
Elucidation of the Genomic-Epigenomic Interaction Landscape of Aggressive Prostate Cancer.
BioMed research international - 1 Jan 2021
Kumar Mamidi Tarun Karthik, Wu Jiande, Hicks Chindo
Abstract excerpt
BACKGROUND: Majority of prostate cancer (PCa) deaths are attributed to localized high-grade aggressive tumours which progress rapidly to metastatic disease. A critical unmet need in clinical management of PCa is discovery and characterization of the molecular drivers of aggressive tumours. The development and progression of aggressive PCa involve genetic and epigenetic alterations occurring in the germline,...
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