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Article

A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.

PLoS genetics - 1 Nov 2014

Williams Kendra A, Lee Minnkyong, Hu Ying, Andreas Jonathan, Patel Shashank J, Zhang Suiyuan, Chines Peter, Elkahloun Abdel, Chandrasekharappa Settara, Gutkind J Silvio, Molinolo Alfredo A, Crawford Nigel P S

Abstract excerpt

Although prostate cancer typically runs an indolent course, a subset of men develop aggressive, fatal forms of this disease. We hypothesize that germline variation modulates susceptibility to aggressive prostate cancer. The goal of this work is to identify susceptibility genes using the C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mouse model of neuroendocrine prostate cancer. Quantitative trait locus (QTL) mapping was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25411967
DOI: 10.1371/journal.pgen.1004809
PMCID: PMC4238980

Genes

CXCL14
ITGAX
LPCAT2
CCL19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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