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The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese

5 Jun 2018

Abstract excerpt

). In addition, we found several pathways enriched in long-lived genomes, including FOXA1 and FOXA transcription factor networks involved in regulating aging or age-dependent diseases such as cancer. Thus, our study has identified longevity-associated CNV regions and their affected genes and pathways. Our results suggest that the human genome structures such as CNVs might play an important role in determining a...

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PMID: 29883365
DOI: 10.18632/aging.101461

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