Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common copy number variation polymorphism in the CNTNAP2 gene: sexual dimorphism in association with healthy aging and disease.

Gerontology - 1 Jan 2015

Iakoubov Leonid, Mossakowska Malgorzata, Szwed Malgorzata, Puzianowska-Kuznicka Monika

Abstract excerpt

BACKGROUND: New therapeutic targets are needed to fight aging-related diseases and increase life span. A new female-specific association with diseases and limited survival past 80 years was recently reported for a copy number variation (CNV) in the CNTNAP4 gene from the neurexin superfamily. OBJECTIVE: We asked whether there are CNVs that are associated with aging phenotypes within other genes from the neurexin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Genome-Wide Association Study

Share to Longevity

Share to Membrane Proteins

Share to Nerve Tissue Proteins

Share to Sex Factors

Source

Identifiers

PMID: 25139204
DOI: 10.1159/000363320

Genes

CNTNAP2
CNTNAP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common copy number variation polymorphism in the CNTNAP2 gene: sexual dimorphism in association with healthy aging and disease.PMID 25139204Read ↗

One CNV Discordance in NRXN1 Observed Upon Genome-wide Screening in 38 Pairs of Adult Healthy Monozygotic Twins.Semantic proximity Read ↗

Genetic variants in the CNTNAP2 gene are associated with gender differences among dyslexic children in China.Semantic proximity Read ↗

The correlation of copy number variations with longevity in a genome-wide association study of Han ChineseSemantic proximity Read ↗

Copy number variations in alternative splicing gene networks impact lifespan.Semantic proximity Read ↗

Novel and known minor alleles of CNTNAP2 gene variants are associated with comorbidity of intellectual disability and epilepsy phenotypes: a case-control association study reveals potential biomarkers.Semantic proximity Read ↗

A higher mutational burden in females supports a "female protective model" in neurodevelopmental disorders.Semantic proximity Read ↗

CNTNAP2 mutations and autosomal dominant epilepsy with auditory features.Semantic proximity Read ↗

Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1.Semantic proximity Read ↗

[Analysis of CNTNAP1 gene variants in a Chinese pedigree affected with lethal congenital contracture syndrome type 7].Semantic proximity Read ↗

CNTNAP2 Is Significantly Associated With Speech Sound Disorder in the Chinese Han Population.Semantic proximity Read ↗

Genome-wide copy number variation association analyses for age at menarche.Semantic proximity Read ↗

The Human Contactin-Associated Protein-like 2 Gene (CNTNAP2) Spans over 2 Mb of DNA at Chromosome 7q35Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.