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Article

Copy number variations in alternative splicing gene networks impact lifespan.

PloS one - 1 Jan 2013

Glessner Joseph T, Smith Albert Vernon, Panossian Saarene, Kim Cecilia E, Takahashi Nagahide, Thomas Kelly A, Wang Fengxiang, Seidler Kallyn, Harris Tamara B, Launer Lenore J, Keating Brendan, Connolly John, Sleiman Patrick M A, Buxbaum Joseph D, Grant Struan F A, Gudnason Vilmundur, Hakonarson Hakon

Abstract excerpt

Longevity has a strong genetic component evidenced by family-based studies. Lipoprotein metabolism, FOXO proteins, and insulin/IGF-1 signaling pathways in model systems have shown polygenic variations predisposing to shorter lifespan. To test the hypothesis that rare variants could influence lifespan, we compared the rates of CNVs in healthy children (0-18 years of age) with individuals 67 years or older. CNVs at...

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Identifiers

PMID: 23382853
DOI: 10.1371/journal.pone.0053846
PMCID: PMC3559729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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