Article
Large common deletions associate with mortality at old age.
Human molecular genetics - 1 Nov 2011
Kuningas Maris, Estrada Karol, Hsu Yi-Hsiang, Nandakumar Kannabiran, Uitterlinden André G, Lunetta Kathryn L, van Duijn Cornelia M, Karasik David, Hofman Albert, Murabito Joanne, Rivadeneira Fernando, Kiel Douglas P, Tiemeier Henning
Abstract excerpt
Copy-number variants (CNVs) are a source of genetic variation that increasingly are associated with human disease. However, the role of CNVs in human lifespan is to date unknown. To identify CNVs that influence mortality at old age, we analyzed genome-wide CNV data in 5178 participants of Rotterdam Study (RS1) and positive findings were evaluated in 1714 participants of the second cohort of the Rotterdam Study...
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