Article
Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment.
Aging cell - 1 Feb 2016
Nygaard Marianne, Debrabant Birgit, Tan Qihua, Deelen Joris, Andersen-Ranberg Karen, de Craen Anton J M, Beekman Marian, Jeune Bernard, Slagboom Pieternella E, Christensen Kaare, Christiansen Lene
Abstract excerpt
Copy number variants (CNVs) represent a significant source of genetic variation in the human genome and have been implicated in numerous diseases and complex traits. To date, only a few studies have investigated the role of CNVs in human lifespan. To investigate the impact of CNVs on prospective mortality at the extreme end of life, where the genetic component of lifespan appears most profound, we analyzed...
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