Article
CNVs-microRNAs interactions demonstrate unique characteristics in the human genome. An interspecies in silico analysis.
PloS one - 1 Jan 2013
Dweep Harsh, Georgiou George D, Gretz Norbert, Deltas Constantinos, Voskarides Konstantinos, Felekkis Kyriacos
Abstract excerpt
MicroRNAs (miRNAs) and copy number variations (CNVs) represent two classes of newly discovered genomic elements that were shown to contribute to genome plasticity and evolution. Recent studies demonstrated that miRNAs and CNVs must have co-evolved and interacted in an attempt to maintain the balance of the dosage sensitive genes and at the same time increase the diversity of dosage non-sensitive genes,...
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