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Article

Phenotypic and genetic characterization of daptomycin non-susceptible Staphylococcus aureus strains selected by adaptive laboratory evolution.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Xu Yanlei, Xiao Yanghua, Zhao Huilin, Wang Bingjie, Yu Jingyi, Shang Yongpeng, Zhou Ying, Wu Xiaocui, Guo Yinjuan, Yu Fangyou

Abstract excerpt

Background: Daptomycin non-susceptible Staphylococcus aureus (DNS) strains pose a serious clinical threat, yet their characteristics remain poorly understood. Methods: DNS derivatives were generated by exposing S. aureus strains to subinhibitory concentrations of daptomycin. Competition experiment and growth kinetics experiment were used to observe the growth of bacteria. Galleria mellonella larvae and mouse skin...

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Identifiers

PMID: 39512591
DOI: 10.3389/fcimb.2024.1453233
PMCID: PMC11540788

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