Article
Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation.
Human molecular genetics - 1 Sept 2018
Chatzifrangkeskou Maria, Yadin David, Marais Thibaut, Chardonnet Solenne, Cohen-Tannoudji Mathilde, Mougenot Nathalie, Schmitt Alain, Crasto Silvia, Di Pasquale Elisa, Macquart Coline, Tanguy Yannick, Jebeniani Imen, Pucéat Michel, Morales Rodriguez Blanca, Goldmann Wolfgang H, Dal Ferro Matteo, Biferi Maria-Grazia, Knaus Petra, Bonne Gisèle, Worman Howard J, Muchir Antoine
Abstract excerpt
Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart dysfunction in cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy). The mechanism of how this affects cardiac function is unknown. We show that active phosphorylated ERK1/2 directly binds to and catalyzes the phosphorylation of the actin depolymerizing factor cofilin-1 on Thr25. Cofilin-1 becomes...
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