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Article

Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene Mutations.

Methods in enzymology - 1 Jan 2016

Muchir Antoine, Worman Howard J

Abstract excerpt

The most frequently occurring mutations in the gene encoding nuclear lamin A and nuclear lamin C cause striated muscle diseases virtually always involving the heart. In this review, we describe the approaches and methods used to discover that cardiomyopathy-causing lamin A/C gene mutations increase MAP kinase signaling in the heart and that this plays a role in disease pathogenesis. We review different mouse...

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Identifiers

PMID: 26795484
DOI: 10.1016/bs.mie.2015.07.028
PMCID: PMC4878678

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