The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies.

doi:10.1016/j.celrep.2021.109601

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Article

The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies.

Cell reports - 24 Aug 2021

Vignier Nicolas, Chatzifrangkeskou Maria, Pinton Luca, Wioland Hugo, Marais Thibaut, Lemaitre Mégane, Le Dour Caroline, Peccate Cécile, Cardoso Déborah, Schmitt Alain, Wu Wei, Biferi Maria-Grazia, Naouar Naïra, Macquart Coline, Beuvin Maud, Decostre Valérie, Bonne Gisèle, Romet-Lemonne Guillaume, Worman Howard J, Tedesco Francesco Saverio, Jégou Antoine, Muchir Antoine

Abstract excerpt

Cofilins are important for the regulation of the actin cytoskeleton, sarcomere organization, and force production. The role of cofilin-1, the non-muscle-specific isoform, in muscle function remains unclear. Mutations in LMNA encoding A-type lamins, intermediate filament proteins of the nuclear envelope, cause autosomal Emery-Dreifuss muscular dystrophy (EDMD). Here, we report increased cofilin-1 expression in...

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Identifiers

PMID: 34433058
DOI: 10.1016/j.celrep.2021.109601
PMCID: PMC8411111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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