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Article

Cell signaling abnormalities in cardiomyopathy caused by lamin A/C gene mutations.

Biochemical Society transactions - 19 Feb 2018

Worman Howard J

Abstract excerpt

Mutations in the lamin A/C gene (LMNA) encoding intermediate filament proteins associated with the inner nuclear membrane cause diseases known as laminopathies. Most LMNA mutations cause dilated cardiomyopathy with variable skeletal muscular dystrophy. Cell signaling abnormalities have been discovered in hearts of mouse models of cardiomyopathy caused by LMNA mutations that contribute to pathogenesis. These...

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Share to Cardiomyopathies
Share to Disease Models, Animal
Share to Lamin Type A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanistic Target of Rapamycin Complex 1

Share to Myocardium

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Share to Signal Transduction

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Source

Open in PubMed Open full text

Identifiers

PMID: 29196611
DOI: 10.1042/BST20170236
PMCID: PMC6521696

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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