Article
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
The Journal of biological chemistry - 24 Aug 2012
Raskin Anna, Lange Stephan, Banares Katherine, Lyon Robert C, Zieseniss Anke, Lee Leonard K, Yamazaki Katrina G, Granzier Henk L, Gregorio Carol C, McCulloch Andrew D, Omens Jeffrey H, Sheikh Farah
Abstract excerpt
Understanding mechanisms underlying titin regulation in cardiac muscle function is of critical importance given recent compelling evidence that highlight titin mutations as major determinants of human cardiomyopathy. We previously identified a cardiac biomechanical stress-regulated complex at the cardiac-specific N2B region of titin that includes four-and-a-half LIM domain protein-1 (Fhl1) and components of the...
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