Article
Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction.
International journal of molecular sciences - 6 Jul 2023
Del Monte-Monge Alberto, Ruiz-Polo de Lara Íñigo, Gonzalo Pilar, Espinós-Estévez Carla, González-Amor María, de la Fuente-Pérez Miguel, Andrés-Manzano María J, Fanjul Víctor, Gimeno Juan R, Barriales-Villa Roberto, Dorado Beatriz, Andrés Vicente
Abstract excerpt
Mutations in the LMNA gene (encoding lamin A/C proteins) cause several human cardiac diseases, including dilated cardiomyopathies (LMNA-DCM). The main clinical risks in LMNA-DCM patients are sudden cardiac death and progressive left ventricular ejection fraction deterioration, and therefore most human and animal studies have sought to define the mechanisms through which LMNA mutations provoke cardiac alterations,...
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