Article
Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.
Circulation. Cardiovascular genetics - 1 Apr 2014
Kocarnik Jonathan M, Pendergrass Sarah A, Carty Cara L, Pankow James S, Schumacher Fredrick R, Cheng Iona, Durda Peter, Ambite José Luis, Deelman Ewa, Cook Nancy R, Liu Simin, Wactawski-Wende Jean, Hutter Carolyn, Brown-Gentry Kristin, Wilson Sarah, Best Lyle G, Pankratz Nathan, Hong Ching-Ping, Cole Shelley A, Voruganti V Saroja, Bůžkova Petra, Jorgensen Neal W, Jenny Nancy S, Wilkens Lynne R, Haiman Christopher A, Kolonel Laurence N, Lacroix Andrea, North Kari, Jackson Rebecca, Le Marchand Loic, Hindorff Lucia A, Crawford Dana C, Gross Myron, Peters Ulrike
Abstract excerpt
BACKGROUND: C-reactive protein (CRP) is a biomarker of inflammation. Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with CRP concentrations and inflammation-related traits such as cardiovascular disease, type 2 diabetes mellitus, and obesity. We aimed to replicate previous CRP-SNP associations, assess whether these associations generalize to additional...
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