Article
[Functional role of DNMT3A mutation in acute myeloid leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2000
Koya Junji, Kurokawa Mineo
Abstract excerpt
A current broad spectrum of genomic studies on acute myeloid leukemia (AML) has demonstrated that a gene encoding for DNA methyltransferase, specifically DNA methyltransferase 3 alpha (DNMT3A) is frequently mutated. However, DNMT3A variants are present in elderly healthy individuals and patients with AML in complete remission, which suggests that DNMT3A mutations may contribute to pre-leukemic clonal...
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