Article
[Analysis of DNMT3a mutation in childhood acute myeloid leukemia].
Zhongguo shi yan xue ye xue za zhi - 1 Dec 2012
Zhou Jian-Feng, Zhang Li, Zeng Hui-Min, Wang Ya-Qin, Yi Xiao-Li, An Wen-Bin, Chang Li-Xian, Zou Yao, Chen Yu-Mei, Zhu Xiao-Fan
Abstract excerpt
Within the past few years, the invention of next-generation sequencing has revealed several new genes associated with tumor formation and development, for example DNMT3a. This gene is an independent prognostic factor for acute myeloid leukemia (AML). The objective of this study was to analyze the DNMT3a mutation in childhood AML in a single center. PCR amplification of the entire coding region of DNMT3a was...
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