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Article

Rapamycin attenuates pathological hypertrophy caused by an absence of trabecular formation.

Scientific reports - 5 Jun 2018

Fleming Nicole D, Samsa Leigh A, Hassel David, Qian Li, Liu Jiandong

Abstract excerpt

Cardiac trabeculae are mesh-like muscular structures within ventricular walls. Subtle perturbations in trabeculation are associated with many congenital heart diseases (CHDs), and complete failure to form trabeculae leads to embryonic lethality. Despite the severe consequence of an absence of trabecular formation, the exact function of trabeculae remains unclear. Since ErbB2 signaling plays a direct and essential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29872120
DOI: 10.1038/s41598-018-26843-1
PMCID: PMC5988815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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