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Article

Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish

15 Jul 2011

Abstract excerpt

RATIONALE: Although a cardioprotective function of target of rapamycin (TOR) signaling inhibition has been suggested by pharmacological studies using rapamycin, genetic evidences are still lacking. We explored adult zebrafish as a novel vertebrate model for dissecting signaling pathways in cardiomyopathy. OBJECTIVE: We generated the second adult zebrafish cardiomyopathy model induced by doxorubicin. By...

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PMID: 21757652
DOI: 10.1161/circresaha.111.248260

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