Zebrafish integrin a3b is required for cardiac contractility and cardiomyocyte proliferation.

Abstract excerpt

In cardiac muscle cells, heterodimeric integrin transmembrane receptors are known to serve as mechanotransducers, translating mechanical force to biochemical signaling. However, the roles of many individual integrins have still not been delineated. In this report, we demonstrate that Itga3b is localized to the sarcolemma of cardiomyocytes from 24 to 96 hpf. We further show that heterozygous and homozygous...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Knockdown Techniques
• Share to Microscopy, Electron, Transmission