Article
Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling.
Nature communications - 9 May 2017
Rasouli S Javad, Stainier Didier Y R
Abstract excerpt
Trabeculation is crucial for cardiac muscle growth in vertebrates. This process requires the Erbb2/4 ligand Neuregulin (Nrg), secreted by the endocardium, as well as blood flow/cardiac contractility. Here, we address two fundamental, yet unresolved, questions about cardiac trabeculation: why does it initially occur in the ventricle and not the atrium, and how is it modulated by blood flow/contractility. Using...
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