Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.

doi:10.1038/ncomms7125

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Article

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.

Nature communications - 27 Jan 2015

Mengelbier Linda Holmquist, Karlsson Jenny, Lindgren David, Valind Anders, Lilljebjörn Henrik, Jansson Caroline, Bexell Daniel, Braekeveldt Noémie, Ameur Adam, Jonson Tord, Kultima Hanna Göransson, Isaksson Anders, Asmundsson Jurate, Versteeg Rogier, Rissler Marianne, Fioretos Thoas, Sandstedt Bengt, Börjesson Anna, Backman Torbjörn, Pal Niklas, Øra Ingrid, Mayrhofer Markus, Gisselsson David

Abstract excerpt

Genetic differences among neoplastic cells within the same tumour have been proposed to drive cancer progression and treatment failure. Whether data on intratumoral diversity can be used to predict clinical outcome remains unclear. We here address this issue by quantifying genetic intratumoral diversity in a set of chemotherapy-treated childhood tumours. By analysis of multiple tumour samples from seven patients...

Topics

Alleles
Antineoplastic Agents
Child
Child, Preschool
Disease Progression
Evolution, Molecular
Genetic Heterogeneity
Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomic Instability

Humans

Neoplasm Metastasis

Neoplasms

Prognosis

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 25625758
DOI: 10.1038/ncomms7125

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