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Article

Cancer: evolution within a lifetime.

Annual review of genetics - 1 Jan 2014

Gerlinger Marco, McGranahan Nicholas, Dewhurst Sally M, Burrell Rebecca A, Tomlinson Ian, Swanton Charles

Abstract excerpt

Subclonal cancer populations change spatially and temporally during the disease course. Studies are revealing branched evolutionary cancer growth with low-frequency driver events present in subpopulations of cells, providing escape mechanisms for targeted therapeutic approaches. Despite such complexity, evidence is emerging for parallel evolution of subclones, mediated through distinct somatic events converging...

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PMID: 25292359
DOI: 10.1146/annurev-genet-120213-092314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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