Evolutionary histories of breast cancer and related clones.

doi:10.1038/s41586-023-06333-9

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Article

Evolutionary histories of breast cancer and related clones.

Nature - 1 Aug 2023

Nishimura Tomomi, Kakiuchi Nobuyuki, Yoshida Kenichi, Sakurai Takaki, Kataoka Tatsuki R, Kondoh Eiji, Chigusa Yoshitsugu, Kawai Masahiko, Sawada Morio, Inoue Takuya, Takeuchi Yasuhide, Maeda Hirona, Baba Satoko, Shiozawa Yusuke, Saiki Ryunosuke, Nakagawa Masahiro M, Nannya Yasuhito, Ochi Yotaro, Hirano Tomonori, Nakagawa Tomoe, Inagaki-Kawata Yukiko, Aoki Kosuke, Hirata Masahiro, Nanki Kosaku, Matano Mami, Saito Megumu, Suzuki Eiji, Takada Masahiro, Kawashima Masahiro, Kawaguchi Kosuke, Chiba Kenichi, Shiraishi Yuichi, Takita Junko, Miyano Satoru, Mandai Masaki, Sato Toshiro, Takeuchi Kengo, Haga Hironori, Toi Masakazu, Ogawa Seishi

Abstract excerpt

Recent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated in cancer development1-3. However, our knowledge is still missing with regard to what additional driver events take place in what order, before one or more of these clones in normal tissues ultimately evolve to cancer. Here, using phylogenetic analyses of multiple...

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PMID: 37495687
DOI: 10.1038/s41586-023-06333-9
PMCID: PMC10432280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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