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Article

Somatic evolutionary timings of driver mutations.

BMC cancer - 18 Jan 2018

Gomez Karen, Miura Sayaka, Huuki Louise A, Spell Brianna S, Townsend Jeffrey P, Kumar Sudhir

Abstract excerpt

BACKGROUND: A unified analysis of DNA sequences from hundreds of tumors concluded that the driver mutations primarily occur in the earliest stages of cancer formation, with relatively few driver mutation events detected in the late-arising subclones. However, emerging evidence from the sequencing of multiple tumors and tumor regions per individual suggests that late-arising subclones with additional driver...

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Identifiers

PMID: 29347918
DOI: 10.1186/s12885-017-3977-y
PMCID: PMC5774140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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