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Article

The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness.

Scientific reports - 4 Jun 2018

Yasmin, Maskari Raya Al, McEniery Carmel M, Cleary Sarah E, Li Ye, Siew Keith, Figg Nichola L, Khir Ashraf W, Cockcroft John R, Wilkinson Ian B, O'Shaughnessy Kevin M

Abstract excerpt

Stiffening of the aorta is an important independent risk factor for myocardial infarction and stroke. Yet its genetics is complex and little is known about its molecular drivers. We have identified for the first time, tagSNPs in the genes for extracellular matrix proteins, aggrecan and fibulin-1, that modulate stiffness in young healthy adults. We confirmed SNP associations with ex vivo stiffness measurements and...

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Identifiers

PMID: 29867203
DOI: 10.1038/s41598-018-25851-5
PMCID: PMC5986773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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