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Genetics of the extracellular matrix in aortic aneurysmal diseases.

Matrix biology : journal of the International Society for Matrix Biology - 1 Oct 2018

Lin Chien-Jung, Lin Chieh-Yu, Stitziel Nathan O

Abstract excerpt

Aortic aneurysms are morbid conditions that can lead to rupture or dissection and are categorized as thoracic (TAA) or abdominal aortic aneurysms (AAA) depending on their location. While AAA shares overlapping risk factors with atherosclerotic cardiovascular disease, TAA exhibits strong heritability. Human genetic studies in the past two decades have successfully identified numerous genes involved in both...

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Aortic Aneurysm
Aortic Aneurysm, Abdominal
Aortic Aneurysm, Thoracic
Extracellular Matrix
Genetic Predisposition to Disease

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Transforming Growth Factor beta

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PMID: 29656146
DOI: 10.1016/j.matbio.2018.04.005
PMCID: PMC6146054

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