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Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities

3 Aug 2022

Abstract excerpt

Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections, as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide associations of ascending and descending aortic distensibility and area derived from cardiac magnetic resonance imaging (MRI) data of up to 32,590 Caucasian individuals in UK Biobank. We identify 102 loci (including 27 novel...

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PMID: 35922433
DOI: 10.1038/s41467-022-32219-x

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