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Article

Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences.

Circulation - 16 Sept 2025

Beeche Cameron, Zhao Bingxin, Tavolinejad Hamed, Pourmussa Bianca, Kim Joonghyun, Duda Jeffrey, Gee James, Witschey Walter R, Chirinos Julio A

Abstract excerpt

BACKGROUND: Vascular aging is an important phenotype characterized by structural and geometric remodeling. Some individuals exhibit supernormal vascular aging, associated with improved cardiovascular outcomes; others experience early vascular aging, linked to adverse cardiovascular outcomes. The aorta is the artery that exhibits the most prominent age-related changes; however, the biological mechanisms underlying...

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PMID: 40671674
DOI: 10.1161/CIRCULATIONAHA.125.074554
PMCID: PMC12278840

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