Article
The Genetics and Typical Traits of Thoracic Aortic Aneurysm and Dissection.
Annual review of genomics and human genetics - 31 Aug 2022
Rodrigues Bento Jotte, Meester Josephina, Luyckx Ilse, Peeters Silke, Verstraeten Aline, Loeys Bart
Abstract excerpt
Genetic predisposition and risk factors such as hypertension and smoking can instigate the development of thoracic aortic aneurysm (TAA), which can lead to highly lethal aortic wall dissection and/or rupture. Monogenic defects in multiple genes involved in the elastin-contractile unit and the TGFβ signaling pathway have been associated with TAA in recent years, along with several genetic modifiers and...
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