Article
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2018
Hemming Matthew L, Lawlor Matthew A, Zeid Rhamy, Lesluyes Tom, Fletcher Jonathan A, Raut Chandrajit P, Sicinska Ewa T, Chibon Frédéric, Armstrong Scott A, Demetri George D, Bradner James E
Abstract excerpt
Activating mutations in the KIT or PDGFRA receptor tyrosine kinases are hallmarks of gastrointestinal stromal tumor (GIST). The biological underpinnings of recurrence following resection or disease progression beyond kinase mutation are poorly understood. Utilizing chromatin immunoprecipitation with sequencing of tumor samples and cell lines, we describe the enhancer landscape of GIST, highlighting genes that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.