Article
Genomic and transcriptomic landscape of human gastrointestinal stromal tumors.
Nature communications - 3 Nov 2024
Xie Feifei, Luo Shuzhen, Liu Dongbing, Lu Xiaojing, Wang Ming, Liu Xiaoxiao, Jia Fujian, Pang Yuzhi, Shen Yanying, Zeng Chunling, Ma Xinli, Tang Daoqiang, Tu Lin, Yang Linxi, Cheng Yumei, Luo Yuxiang, Xie Fanfan, Hou Hao, Huang Tao, Ni Bo, Zhuang Chun, Zhao Wenyi, Li Ke, Zheng Xufen, Bi Wenbo, Jia Xiaona, He Yi, Wang Simin, Cao Hui, Wu Kui, Wang Yuexiang
Abstract excerpt
Gastrointestinal stromal tumor (GISTs) are clinically heterogenous exhibiting varying degrees of disease aggressiveness in individual patients. We comprehensively describe the genomic and transcriptomic landscape of a cohort of 117 GISTs including 31 low-risk, 18 intermediate-risk, 29 high-risk, 34 metastatic and 5 neoadjuvant GISTs from 105 patients. GISTs have notably low tumor mutation burden but widespread...
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