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Article

Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs.

Nature - 1 Nov 2019

Flavahan William A, Drier Yotam, Johnstone Sarah E, Hemming Matthew L, Tarjan Daniel R, Hegazi Esmat, Shareef Sarah J, Javed Nauman M, Raut Chandrajit P, Eschle Benjamin K, Gokhale Prafulla C, Hornick Jason L, Sicinska Ewa T, Demetri George D, Bernstein Bradley E

Abstract excerpt

Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1-3. A subset of gastrointestinal stromal tumours (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase (SDH) deficiency and global DNA hyper-methylation4,5. Here, we associate this hyper-methylation with changes in genome topology that activate oncogenic programs. To...

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Source

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Identifiers

PMID: 31666694
DOI: 10.1038/s41586-019-1668-3
PMCID: PMC6913936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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