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An integrative epigenomic approach identifies ELF3 as an oncogenic regulator in ASCL1 ‐positive neuroendocrine carcinoma

25 Feb 2023

Abstract excerpt

Neuroendocrine carcinoma (NEC) is a highly aggressive subtype of the neuroendocrine tumor with an extremely poor prognosis. We have previously conducted a comprehensive genomic analysis of over 100 cases of NEC of the gastrointestinal system (GIS-NEC) and unraveled its unique and organ-specific genomic drivers. However, the epigenomic features of GIS-NEC remain unexplored. In this study, we have described the...

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PMID: 36840413
DOI: 10.1111/cas.15764

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