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Article

Prostate Power Play: Does Pik3ca Accelerate Pten -Deficient Cancer Progression?

31 May 2018

Abstract excerpt

Abstract Summary: PI3K pathway alterations are frequently recurrent in metastatic prostate cancer and are associated with the development of currently incurable castration-resistant disease. Candidate inhibitors that target single PI3K pathway members lack efficacy as demonstrated in multiple clinical trials. In this issue, Pearson and colleagues examine the functional importance of co-occurring PIK3CA and PTEN...

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PMID: 29858226
DOI: 10.1158/2159-8290.cd-18-0369

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