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Article

Androgen deprivation induces phenotypic plasticity and promotes resistance to molecular targeted therapy in a PTEN-deficient mouse model of prostate cancer.

Carcinogenesis - 1 Sept 2014

De Velasco Marco A, Tanaka Motoyoshi, Yamamoto Yutaka, Hatanaka Yuji, Koike Hiroyuki, Nishio Kazuto, Yoshikawa Kazuhiro, Uemura Hirotsugu

Abstract excerpt

Castration-resistant prostate cancer is an incurable heterogeneous disease that is characterized by a complex multistep process involving different cellular and biochemical changes brought on by genetic and epigenetic alterations. These changes lead to the activation or overexpression of key survival pathways that also serve as potential therapeutic targets. Despite promising preclinical results, molecular...

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Identifiers

PMID: 24986896
DOI: 10.1093/carcin/bgu143
PMCID: PMC4146423

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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