Article

PTEN regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression

2023-05-16

Abstract excerpt

<title>Abstract</title> <p><italic>PTEN</italic> loss, one of the most frequent mutations in prostate cancer (PC), is presumed to drive disease progression through AKT activation. However, two transgenic PC models with Akt activation plus <italic>Rb</italic> loss exhibited different metastasis development: <italic>Pten/Rb</italic><sup><italic>PE:−/−</italic></sup> mice produced systemic metastatic adenocarcinomas...

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Literature Corpus work: dea90f42-5ff6-5739-be06-f90e8856dedb
DOI: 10.21203/rs.3.rs-2924750/v1

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