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Article

PIK3/Akt/mTOR pathway alterations in metastatic castration-sensitive prostate cancer.

The Prostate - 1 Oct 2024

Sutera Philip, Kim Jongmyung, Kumar Ritesh, Deek Rebecca A, Stephenson Ryan, Mayer Tina, Saraiya Biren, Ghodoussipour Saum, Jang Thomas, Golombos David, Packiam Vignesh, Ennis Ronald, Hathout Lara, Jabbour Salma K, Guler Ozan, Onal Cem, Tran Phuoc T, Deek Matthew P

Abstract excerpt

BACKGROUND: Alterations in the PIK3/Akt/mTOR pathway are commonly seen in metastatic castration-sensitive prostate cancer (mCSPC), however their role in outcomes is unknown. We aim to evaluate the prognostic significance as well as the genetic landscape of PIK3/Akt/mTOR pathway alteration in mCSPC. METHODS: Fourhundred and seventy-two patients with mCSPC were included who underwent next generation sequencing....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Prostatic Neoplasms, Castration-Resistant

Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 39021052
DOI: 10.1002/pros.24765

Genes

ERG
PIK3CA
PIK3CB
PTEN
TMPRSS2
TP53
TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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