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Article

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.

The Journal of pathology - 1 Dec 2017

Jefferies Matthew T, Cox Adam C, Shorning Boris Y, Meniel Valerie, Griffiths David, Kynaston Howard G, Smalley Matthew J, Clarke Alan R

Abstract excerpt

Aberrant phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase (MAPK) and WNT signalling are emerging as key events in the multistep nature of prostate tumourigenesis and progression. Here, we report a compound prostate cancer murine model in which these signalling pathways cooperate to produce a more aggressive prostate cancer phenotype. Using Cre-LoxP technology and the probasin promoter, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29134654
DOI: 10.1002/path.4977
PMCID: PMC6128396

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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