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Article

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

5 Apr 2014

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Share to Autophagy in Disease and Therapy
Share to Mitochondrial Function and Pathology
Share to Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24709290
DOI: 10.1016/j.bbamcr.2014.03.027

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Related research

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Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagyPMID 24709290Read ↗

Progress in research on the role of Omi/HtrA2 in neurological diseasesSemantic proximity Read ↗

The mitochondrial serine protease HtrA2/Omi: an overviewSemantic proximity Read ↗

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.Semantic proximity Read ↗

The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell deathSemantic proximity Read ↗

Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.Semantic proximity Read ↗

HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.Semantic proximity Read ↗

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy ReceptorSemantic proximity Read ↗

Cell autonomous inflammation in VEXAS is mediated by cGAS-STINGSemantic proximity Read ↗

A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex restrains excessive mitophagy to prevent mitochondrial diseaseSemantic proximity Read ↗

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant miceSemantic proximity Read ↗

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKαSemantic proximity Read ↗

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.Semantic proximity Read ↗

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