Article

SARS-CoV-2 papain-like protease inhibits IL-1β maturation and pyroptosis through disruption of ASC oligomerization and deubiquitination of ASC

2023-01-24

Abstract excerpt

The perplexing innate immune response induced by SARS-CoV-2 infection remains inadequate uncovered. Previous studies showed that coronavirus papain-like protease (PLP) could evade type I interferons mediated innate immune responses. In this study, we found the inflammasome genes (NLRP3, NLRP6, PYCARD, IL1B, IL18, TRIM31, FBXL2, MARCH7) were down-regulated in CD14+ monocytes from COVID-19 patients. Secondly, we fou...

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Literature Corpus work: e31088da-ad7c-535c-88fa-bd4f11a786bf
DOI: 10.22541/au.167458073.32400363/v1

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